RELION-5, AreTomo, Warp/M, IsoNet, MemBrain, MotionCor3, CTFFIND4, Topaz — verified containers, multi-GPU, Slurm-orchestrated. Multi-TB tilt-series stay in your VPC. We containerize the new methods that drop quarterly so your team doesn't have to.
Plans from $99/mo BYOC · free 30-day pilot · How we compare to CryoCloud →
We ran the full RELION-tomo STA pipeline on EMPIAR-10164 (immature HIV-1 Gag) on Clusterra: AreTomo2 tilt-series alignment → RELION-tomo particle extraction → gold-standard 3D refinement. Gold-standard FSC resolution: 3.99 Å. Total GPU cost on 4× T4 spot: ~$2.30.
Pinned versions, GPU-tuned, multi-node where applicable. The exact things you'd install on a fresh academic cluster, minus the install.
Tilt-series and reconstructed tomograms stay in your S3 bucket. Cross-account IAM, your KMS keys, your audit trail. We never see the data.
Skip the 2-week academic-cluster waitlist. Pay only for the GPU-hours you use. Multi-GPU NCCL + EFA for large refinements; spot checkpoint-restart for long jobs.
IsoNet, MemBrain, AreTomo, Warp/M — we track the field. When the next denoiser or picker drops, we container-build and ship it. You don't maintain a custom RELION install with five patches.
· 5–50 person structural-biology biotech (cellular cryo-ET, drug-target structure)
· Or a cryo-EM core facility serving industry users
· Running RELION / AreTomo / Warp pipelines on aging on-prem GPUs or shared academic clusters
· Need GPU + fast scratch for tomogram reconstruction and subtomogram averaging
· Want a managed catalog of frontier OSS tools (IsoNet, MemBrain, etc.) without maintaining containers yourself
· Your pipeline is fully on cryoSPARC and the license is happy
· You have an in-house cryo-EM IT team running your own cluster
· You only do SPA (single-particle), not cryo-ET — the wedge here is in-cell tomography
· You need SOC 2 / FedRAMP in month one
· Microscope time is your only bottleneck and processing turnaround doesn't matter
All runs on Clusterra — managed Slurm, BYOC, spot EC2.
Immature HIV-1 Gag subtomogram average. AreTomo2 tilt-series alignment → RELION-tomo gold-standard refinement. 4× T4 spot, ~$2.30 total. Full end-to-end STA pipeline.
Multi-GPU RELION-5 3D classification and refinement on a public EMPIAR dataset. Same managed Slurm stack; demonstrates the SPA pipeline for teams running both SPA and cryo-ET.
30× WGS in 2h 32m for ~$2.59/sample. Parabricks GPU alignment + DeepVariant. F1=0.9966 against GIAB. Demonstrates large-input pipelines under spot preemption.
Free 30-day pilot. Your data in your account, RELION-5 + AreTomo2 running before the scoping call ends — no charge. Plans from $99/mo BYOC.